Font: Agencia de Calidad del Sistema Nacional de Salud Posted: 15 Oct 2008 02:04 AM CDT
"Un estudio publicado en JAMA no muestra que la suplementación sea beneficiosa, auque ésta disminuya los niveles de homocisteína ¿Se debe continuar con los ensayos o cerrar definitivamente este capítulo?."
"Artículos de referencia:
Christine M. Albert; Nancy R. Cook; J. Michael Gaziano; Elaine Zaharris, BA; Jean Macafayden, ET AL. Effect of Folic Acid and B Vitamins on Risk of Cardiovascular Events and Total Mortality Among Women at High Risk for Cardiovascular Disease. A Randomized Trial . JAMA.2008;299(17):2027-2036.
1. Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA. 2002;288(16):2015-22.
2. Homocysteine Lowering Trialists’ Collaboration. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. BMJ. 1998;316(7135):894-8.
3. Bazzano LA, Reynolds K, Holder KN, He J. Effect of folic acid supplementation on risk of cardiovascular diseases: a meta-analysis of randomized controlled trials. JAMA. 2006;296(22):2720-26.
4. Carlsson CM. Lowering homocysteine for stroke prevention. Lancet. 2007;369(9576):1841-42.
5. Lonn E, Yusuf S, Arnold MJ; et al. Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med. 2006;354(15):1567-77.
6. Toole JF, Malinow MR, Chambless LE; et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA. 2004;291(5):565-75.
Fuente: Suplemento Impacto de la Agencia de Calidad del Sistema Nacional de Salud. Ocubre 2008;1(8). Actualidad.
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